Yeah, I haven't been able to find any experiences with Wellbutrin and Saffron. BTW, Saffron may also increase dopamine and norepinephrine so it's possible it could increase the side effects. Though, I can't find any studies done in humans that assess its mechanism of action. In-vitro and animal studies are mostly useless and don't translate to humans. Even in humans, multiple studies need to be done to confidently confirm the mechanism of action.
There's also the possibility that chronic dosing alters the compounds that make it to the bloodstream through liver enzyme induction or inhibition, which further changes its pharmacology.
Not sure why SNDRIs aren't available but it seems the safest option for pharmaceutical companies was to target serotonin, which is why so many SSRIs are available, including the newer ones that target some serotonin receptors like Vortioxetine.
I believe that a certain threshold of dopamine transporter inhibition needs to be reached and in a rapid manner for recreational effects to be produced. So time-released pills would solve the issue with the addiction concern. Plus, chronic dosing is likely to result in tolerance.
SNDRIs are also more likely to be 'dirty' in that they target other receptors and even other neurotransmitters. This may produce unpleasant effects for a recreational user.
But yeah it's as you said, triple inhibition would likely be dramatically superior to the current antidepressants. It'd be similar to the MAOIs, which are the most effective antidepressants on the market today.
