Selegiline thread

Galaxyshock

I'm interested in trying Selegiline but unfortunately I don't think I can get it prescribed (it's only approved for Parkinson's treatment in Finland). I wonder if there's some other route I could get my hands on it.

Neuro mentioned it helping his cognition and Selegiline potentiates other substances.

Generally it seems to be well tolerated drug and has shown anti-aging properties.

Would be great to hear anecdotes and also, what is the optimal dosage?

Neuro

That's unfortunate, can you not get it prescribed off-label in Finland?

Yeah, Selegiline is a great drug with lots of positive research on it. It's also very cheap if you split the 5 mg tablet into 4 pieces and take 1.25 mg sublingually. Sublingual administration is the most optimal path because it bypasses the first-pass metabolism, which would otherwise create levoamphetamine and levomethamphetamine metabolites. Though this might differ for some people if they prefer noradrenergic stimulation.

Galaxyshock

I don't know if I could get it prescribed off-label, perhaps I could suggest it to a doctor but I would probably need pretty good reasoning for it hehe. Selegiline is a MAOI and I'm on Duloxetine so they may be hesitant to prescribe it. Even if in low doses Selegiline only inhibits MAOB.

qewret

~~duloxetine~~ reboxetine prevents MAOI induced hypertensive crisis, duloxetine might help a bit too though. MoA is preventing tyramine uptake.

Galaxyshock

qewret

Good to know. Reboxetine is like a brother of Duloxetine? hehe, looks like it's a pure noradrenaline re-uptake inhibitor whereas Duloxetine is quite potent serotonin re-uptake inhibitor along with the NRI mechanism. Reboxetine perhaps can be combined with a MAOI (of both A and B) but not Duloxetine since there would be risk of serotonin syndrome?