Nootropics that you found harmful

Galaxyshock

I guess this side of nootropics needs some attention. Generally nootropics are considered safe, but some can cause side-effects. Usually it's the more exotic and synthetic ones that have this negative side to them.

In my personal experience these nootropics I now stay away from:

Phenibut: Notorious for causing addiction, tolerance and withdrawal. If you have addiction tendencies, don't even try it. Somebody called it "the heroin of nootropics". Not saying Phenibut is some evil drug - it's just a drug with certain effects and some can use it properly, kinda similar to benzos or pregabalin. Personally I couldn't use it properly and fell in to the addiction several times and faced bad withdrawals.
Sulbutiamine: Initially gave me a strong calming effect but in continuous use also started to induce panic symptoms.
Muira Puama: Caused anxiety

Those three came first to my mind, but there are probably more, I'll post again later but let's get this discussion going. 🙂

Neuro

Great thread, it's important that people realize everyone reacts differently. I personally found Piracetam induced severe melancholic depression. Choline exacerbated the effect too.

Galaxyshock

I've never tried plain Piracetam but have other racetams with mostly good/neutral effects. Yeah cholinergics can exacerbate depression, I noticed it when combining Huperzine A with other cholinergics.

D-aspartic acid, well perhaps not a nootropic but quite common supplement, increased acne and sort of amplified anxiety. I think its because of agonism at NMDA-receptors. This was with 3000 mg dosage, but if I take only 1500 mg with some magnesium, the negative effects are reduced greatly.