I've noticed that after taking selegiline or rasagiline for 2 weeks, my perception of time changes. An hour feels a lot longer and a month feels like a long period of time. I did a bit of research and found that the basal ganglia and the substantia nigra are both involved in time perception. Selegiline increases glucose metabolism in the basal ganglia and increases dopamine in the substantia nigra:
Dopamine neurons in a brain region known as the substantia nigra pars compacta can alter the perception of time, according to new research published in Science in December. Stimulating or inhibiting these cells makes mice behave as if time is moving faster or slower, the researchers found. More specifically, boosting dopamine activity slows down the animals’ internal clock, leading them to underestimate time intervals.
https://www.simonsfoundation.org/features/foundation-news/scgb-news/dopamine-cells-influence-our-perception-of-time/
For example, the internal clock used to time durations in the seconds-to-minutes range appears linked to dopamine (DA) function in the basal ganglia, while temporal memory and attentional mechanisms appear linked to acetylcholine (ACh) function in the frontal cortex.
http://www.sciencedirect.com/science/article/pii/0926641096000092
[18F]-Fluorodeoxyglucose positron emission tomography (FDG-PET) showed increased glucose metabolism in the bilateral basal ganglia after initiating selegiline treatment; blood dopamine levels were also increased after selegiline treatment.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804584/
Thoughts?
